We examined a natural history of opioid overdose deaths from 1999-2021 in the United States to describe state-level spatio-temporal heterogeneity in the waves of the epidemic. We obtained overdose death counts by state from 1999-2021. categorized as involving prescription opioids. heroin. https://www.parisnaturalfoodes.shop/product-category/almond-vanilla-unsweetend/