Interaction between filovirus glycoprotein (GP) and the Niemann-Pick C1 (NPC1) protein is essential for membrane fusion during virus entry. Some single-nucleotide polymorphism (SNPs) in two surface-exposed loops of NPC1 are known to reduce viral infectivity. However. the dependence of differences in entry efficiency on SNPs remains unclear. https://www.markymarkscott.com/product-category/developer-6-20-vol/
Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule.
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