Abstract The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress. hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4). We hypothesized that ATF4 is essential for the adaptation of human glioblastoma (GB) cells to the conditions of the tumor microenvironment... https://www.crochetandknitshop.com/product-category/milk-thistle/